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KMID : 0363220180560070437
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Korean Journal of Dermatology
2018 Volume.56 No. 7 p.437 ~ p.442
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Three Cases of Generalized Granuloma Annulare Successfully Treated with Methotrexate
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Cheon Sang-Jin
Park Sung-Min
Lee Hyun-Joo
Kim Tae-Wook
Jin Hyun-Ju
You Hyang-Suk
Shim Woo-Haing
Kim Gun-Wook
Kim Hoon-Soo
Ko Hyun-Chang
Kim Moon-Bum
Kim Byung-Soo
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Abstract
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Granuloma annulare is a benign granulomatous skin disease, clinically characterized by dermal papules tending to form annular shapes. Granuloma annulare is classified into localized, generalized, subcutaneous, and perforating types. Localized granuloma annulare is likely to resolve spontaneously, while generalized granuloma annulare usually takes a chronic course. Topical steroids, phototherapy, isotretinoin, dapsone, hydroxychloroquine, and other various treatments have been proposed, but some cases have been resistant to all of those treatment modalities. We experienced 3 cases of generalized granuloma annulare demonstrating a recalcitrant course that were successfully treated with methotrexate and propose that methotrexate may be an effective option for recalcitrant generalized granuloma annulare treatment.
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KEYWORD
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Generalized granuloma annulare, Recalcitrant, Methotrexate
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